Semaglutide vs. Tirzepatide: Frequently Asked Questions About Our GLP-1 Treatments
At Appell & Sorrell Wellness, we offer two of the most effective FDA-approved medications for weight management today: semaglutide and tirzepatide. Both have helped thousands of patients lose weight, improve metabolic health, and finally feel in control of their appetite again.
Because many new patients ask, “Which one should I choose?” we’ve put together this simple FAQ guide to help you understand the differences, and how we can guide you toward the best option for your body and goals.
FAQ
What’s the difference between semaglutide and tirzepatide?
Both medications help you lose weight by regulating appetite, slowing digestion, and improving how your body uses insulin.
Semaglutide works on the GLP-1 receptor, the hormone pathway that helps control hunger.
Tirzepatide works on two receptors — GLP-1 and GIP — giving it a broader metabolic effect.
Which medication leads to more weight loss?
Both are highly effective, but research shows:
Semaglutide: average 12–15% body weight reduction
Tirzepatide: average 20–22% body weight reduction
However, what matters most is:
✔ your health history
✔ your dose tolerance
✔ consistency
✔ lifestyle factors
Our medical team will help you predict which option will give you the best results.
How quickly do they start working?
Many patients notice appetite changes within the first 1–2 weeks on either medication.
Tirzepatide sometimes produces quicker early appetite suppression, while semaglutide tends to provide a smoother, steadier ramp-up.
Which has stronger appetite control?
Most patients report that tirzepatide feels “stronger” (especially at mid-to-high doses) because of its dual hormone effect.
Semaglutide still provides excellent appetite reduction and may feel more gradual and gentle.
How often are injections given? Do you help me with them?
Both medications are once-weekly injections, taken on the same day each week. Pricing varies between GLP‑1 therapies, and we offer flexible supply options to fit your lifestyle with weekly, monthly, or quarterly plans. Contact us for pricing details.
Yes, we absolutely help.
At your first visit, a nurse will assist you with the injection and guide you step-by-step until you’re completely comfortable. We provide full training, hands-on support, and clear take-home instructions so you feel confident administering your dose at home.
If you ever need additional help or prefer ongoing in-clinic administration, we’re happy to work with you on how we can provide that support.
How do I know which medication is right for me?
That’s exactly what our medical team is here for.
We start with a thorough evaluation, including:
Your weight-loss history and current BMI
Appetite patterns and eating habits
Gastrointestinal sensitivities
Your personal health and wellness goals
Any past experience with GLP‑1 medications
Each patient receives a one-on-one consultation with our nurse practitioner, who reviews your health history, answers questions, and helps guide the plan that’s right for you. From there, we develop a customized treatment plan designed around your unique needs and goals. We also provide scheduled follow-up appointments with a licensed medical professional to monitor your progress, address any questions, and adjust your personalized care plan as needed.
Call 205.593.4371 to schedule your first in person consultation or book online with us.
The content provided is for informational purposes only and does not constitute medical advice. GLP‑1 therapy is prescribed exclusively by a licensed healthcare provider following an in-person consultation and assessment of individual health factors.
